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SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.5
USERS' SCORE
Good
Based on 26 Reviews
8.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
Vitamin D improves heart disease factors
The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.
Direct relevance to cardiovascular health
We conducted a double-blind, randomized clinical trial to see how treating vitamin D deficiency could influence heart health, particularly in patients with ischemic heart disease (IHD). In our study, 44 IHD patients aged 40 to 65 were treated with either vitamin D or a placebo to assess changes in their lipid profiles and C-reactive protein (CRP) levels.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Read More
7
Vitamin D3 aids heart health
Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts.
Significant relevance to heart disease
We explored the effects of vitamin D3 (VitD) on heart cells, focusing on its ability to counteract changes induced by angiotensin II (Ang II), a compound that can contribute to heart disease. The study involved exposing H9c2 cardiomyoblasts—heart muscle cells—to Ang II alone, and then to both Ang II and VitD to see how VitD might help.
Our findings revealed that while VitD effectively reduced the size of the cells and helped lower markers of hypertrophy (a condition where heart cells enlarge often due to strain), it did not significantly improve cell survival in the absence of a protein called sirtuin-1 (SIRT1). When SIRT1 was inhibited, VitD was unable to protect the cells as it normally would. This suggests that SIRT1 is crucial for the pro-survival benefits of vitamin D.
Importantly, while VitD showed promise in tackling hypertrophy, its protective effects rely heavily on SIRT1 being present. This could lead to new ideas for therapies in heart disease, where activating SIRT1 might enhance the benefits of vitamin D to improve heart health.
Our findings revealed that while VitD effectively reduced the size of the cells and helped lower markers of hypertrophy (a condition where heart cells enlarge often due to strain), it did not significantly improve cell survival in the absence of a protein called sirtuin-1 (SIRT1). When SIRT1 was inhibited, VitD was unable to protect the cells as it normally would. This suggests that SIRT1 is crucial for the pro-survival benefits of vitamin D.
Importantly, while VitD showed promise in tackling hypertrophy, its protective effects rely heavily on SIRT1 being present. This could lead to new ideas for therapies in heart disease, where activating SIRT1 might enhance the benefits of vitamin D to improve heart health.
Read More
3
Vitamin D3's limited heart health effects
Vitamin D and cardiovascular outcomes in multiple sclerosis.
Moderate relevance due to limitations
We explored the connection between vitamin D levels and cardiovascular health in people with multiple sclerosis (pwMS). Specifically, our study examined the effects of vitamin D3 treatment on heart-related outcomes among patients with differing levels of vitamin D. Using data from 70 healthcare organizations over a period of five years, we focused on individuals who had either deficient or adequate vitamin D levels.
Our findings revealed that pwMS with deficient or inadequate vitamin D levels experienced an increased risk of major adverse cardiovascular events (MACE), including heart attacks and strokes. Importantly, while some pwMS received cholecalciferol (a form of vitamin D3) supplementation, this did not significantly reduce their risk of heart problems compared to those with adequate vitamin D levels who were not taking supplements.
Overall, our inquiry shows that simply having adequate vitamin D is crucial, but supplementation with vitamin D3 alone may not confer the expected cardiovascular protective benefits for pwMS. This suggests that more comprehensive strategies may be needed to address heart health in these patients.
Our findings revealed that pwMS with deficient or inadequate vitamin D levels experienced an increased risk of major adverse cardiovascular events (MACE), including heart attacks and strokes. Importantly, while some pwMS received cholecalciferol (a form of vitamin D3) supplementation, this did not significantly reduce their risk of heart problems compared to those with adequate vitamin D levels who were not taking supplements.
Overall, our inquiry shows that simply having adequate vitamin D is crucial, but supplementation with vitamin D3 alone may not confer the expected cardiovascular protective benefits for pwMS. This suggests that more comprehensive strategies may be needed to address heart health in these patients.
Read More
Most Useful Reviews
9.5
Immunity boost
I take one capsule of vitamin D3 daily. It reliably supports my body’s immunity against various viral diseases. Over the years of regular intake, my family, including children, has not experienced any significant illness, only mild colds. As someone with thyroid disease, this supplement is essential for me as vitamin D deficiency is linked to autoimmune conditions such as Hashimoto's and even type 1 diabetes, enhancing my resistance to cardiovascular disease.
Read More
9.5
Vitamin D levels
This is a great product! After taking it, my vitamin D levels increased from 27 ng/ml to 84 ng/ml. My doctor advised me to take 5000 units daily in winter and every other day in summer. My thyroid gland has been removed, so maintaining vitamin D is crucial for me. It aids calcium absorption and plays a significant role in preventing complications related to cardiovascular disease, while also enhancing immune response.
Read More
9.5
Essential health support
Vitamin D helps maintain healthy bones and gums and supports cardiovascular function. I take my supplement in the morning with fatty foods. Many lack sufficient vitamin D, and higher doses are warranted. I appreciate this essential nutrient for overall health.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.5
8
Vitamin D improves heart disease factors
The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.
Direct relevance to cardiovascular health
We conducted a double-blind, randomized clinical trial to see how treating vitamin D deficiency could influence heart health, particularly in patients with ischemic heart disease (IHD). In our study, 44 IHD patients aged 40 to 65 were treated with either vitamin D or a placebo to assess changes in their lipid profiles and C-reactive protein (CRP) levels.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Read More
7
Vitamin D3's influence on CVD risk
Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study.
Moderate relevance due to partial findings
We explored how different vitamin D treatments may influence cardiovascular disease (CVD) risk among patients with chronic kidney disease (CKD). Our observational study included 83 CKD patients who were treated with vitamin D or its analogs and had varying histories of CVD. By measuring the thickness of perirenal adipose tissue (PAT) and assessing clinical parameters, we aimed to uncover any links between vitamin D treatment and cardiovascular health.
We found that patients with a history of CVD showed thicker PAT compared to those without such a history. Interestingly, our comparisons among patients receiving different forms of vitamin D revealed that those treated with paricalcitol had less PAT accumulation than those on cholecalciferol or calcitriol. This suggests that the type of vitamin D treatment may play a role in managing CVD risk in CKD patients.
Although our findings indicate differences in PAT thickness related to vitamin D treatment, we did not conduct a controlled trial that would allow us to claim a definitive benefit of vitamin D3 alone on cardiovascular health. It appears that further investigation is necessary to clarify these relationships and understand the mechanisms at play.
We found that patients with a history of CVD showed thicker PAT compared to those without such a history. Interestingly, our comparisons among patients receiving different forms of vitamin D revealed that those treated with paricalcitol had less PAT accumulation than those on cholecalciferol or calcitriol. This suggests that the type of vitamin D treatment may play a role in managing CVD risk in CKD patients.
Although our findings indicate differences in PAT thickness related to vitamin D treatment, we did not conduct a controlled trial that would allow us to claim a definitive benefit of vitamin D3 alone on cardiovascular health. It appears that further investigation is necessary to clarify these relationships and understand the mechanisms at play.
Read More
7
Vitamin D3 aids heart health
Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts.
Significant relevance to heart disease
We explored the effects of vitamin D3 (VitD) on heart cells, focusing on its ability to counteract changes induced by angiotensin II (Ang II), a compound that can contribute to heart disease. The study involved exposing H9c2 cardiomyoblasts—heart muscle cells—to Ang II alone, and then to both Ang II and VitD to see how VitD might help.
Our findings revealed that while VitD effectively reduced the size of the cells and helped lower markers of hypertrophy (a condition where heart cells enlarge often due to strain), it did not significantly improve cell survival in the absence of a protein called sirtuin-1 (SIRT1). When SIRT1 was inhibited, VitD was unable to protect the cells as it normally would. This suggests that SIRT1 is crucial for the pro-survival benefits of vitamin D.
Importantly, while VitD showed promise in tackling hypertrophy, its protective effects rely heavily on SIRT1 being present. This could lead to new ideas for therapies in heart disease, where activating SIRT1 might enhance the benefits of vitamin D to improve heart health.
Our findings revealed that while VitD effectively reduced the size of the cells and helped lower markers of hypertrophy (a condition where heart cells enlarge often due to strain), it did not significantly improve cell survival in the absence of a protein called sirtuin-1 (SIRT1). When SIRT1 was inhibited, VitD was unable to protect the cells as it normally would. This suggests that SIRT1 is crucial for the pro-survival benefits of vitamin D.
Importantly, while VitD showed promise in tackling hypertrophy, its protective effects rely heavily on SIRT1 being present. This could lead to new ideas for therapies in heart disease, where activating SIRT1 might enhance the benefits of vitamin D to improve heart health.
Read More
7
Vascular calcification insights explored
Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling.
Study complexity reduces clarity
In exploring how vitamin D3 influences cardiovascular disease, we conducted experiments with both young and aged mice, who were treated with vitamin D3 or saline to assess its impact on vascular calcification. Out of our findings, it was crucial to note that while vitamin D3 treatments were utilized, we also incorporated Elabela and other compounds, making it challenging to isolate vitamin D3's specific effects on cardiovascular health fully.
Through our study, we observed the potential protective role of Elabela against vascular calcification, particularly acting through pathways that involve PPAR-γ and FDX1 signaling. However, the combination of treatments lacks clarity on the specific benefits of vitamin D3 by itself in managing vascular health. Thus, the data does not present a clear advantage for vitamin D3 in reducing cardiovascular disease risks when considered independently from Elabela.
Overall, our research underlines the complexity of vitamin D3's role in cardiovascular conditions and indicates that more targeted studies are necessary to define its specific contributions clearly.
Through our study, we observed the potential protective role of Elabela against vascular calcification, particularly acting through pathways that involve PPAR-γ and FDX1 signaling. However, the combination of treatments lacks clarity on the specific benefits of vitamin D3 by itself in managing vascular health. Thus, the data does not present a clear advantage for vitamin D3 in reducing cardiovascular disease risks when considered independently from Elabela.
Overall, our research underlines the complexity of vitamin D3's role in cardiovascular conditions and indicates that more targeted studies are necessary to define its specific contributions clearly.
Read More
7
Vitamin D3's cardiovascular association analyzed
[Association of serum 25(OH)D with cardiovascular risk-related indicators: cross-sectional analysis of NHANES].
Depicts moderate relevance to treatment
We explored how serum levels of vitamin D3, specifically 25(OH)D, might influence various indicators related to cardiovascular health. Using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2015 to 2018, we analyzed results from 4,727 adults aged 20 and above.
Our investigation focused on several key factors such as body mass index, high-density lipoprotein cholesterol, systolic blood pressure, and cholesterol levels. The results showed that even a slight increase in vitamin D3 levels was associated with positive changes across these cardiovascular risk factors. For instance, we found that a 1 nmol/L increase in serum 25(OH)D led to small but significant improvements in several indicators.
Notably, the effects varied by gender and age, with women showing greater sensitivity to vitamin D3 levels compared to men, while older adults were less responsive. However, our findings highlighted a complex relationship, revealing nonlinear patterns that suggest additional research is necessary to fully understand these dynamics. While the results display promising associations, they do not confirm that vitamin D3 treatment can directly improve cardiovascular disease outcomes.
Our investigation focused on several key factors such as body mass index, high-density lipoprotein cholesterol, systolic blood pressure, and cholesterol levels. The results showed that even a slight increase in vitamin D3 levels was associated with positive changes across these cardiovascular risk factors. For instance, we found that a 1 nmol/L increase in serum 25(OH)D led to small but significant improvements in several indicators.
Notably, the effects varied by gender and age, with women showing greater sensitivity to vitamin D3 levels compared to men, while older adults were less responsive. However, our findings highlighted a complex relationship, revealing nonlinear patterns that suggest additional research is necessary to fully understand these dynamics. While the results display promising associations, they do not confirm that vitamin D3 treatment can directly improve cardiovascular disease outcomes.
Read More
User Reviews
USERS' SCORE
Good
Based on 26 Reviews
8.8
9.5
Immunity boost
I take one capsule of vitamin D3 daily. It reliably supports my body’s immunity against various viral diseases. Over the years of regular intake, my family, including children, has not experienced any significant illness, only mild colds. As someone with thyroid disease, this supplement is essential for me as vitamin D deficiency is linked to autoimmune conditions such as Hashimoto's and even type 1 diabetes, enhancing my resistance to cardiovascular disease.
Read More
9.5
Vitamin D levels
This is a great product! After taking it, my vitamin D levels increased from 27 ng/ml to 84 ng/ml. My doctor advised me to take 5000 units daily in winter and every other day in summer. My thyroid gland has been removed, so maintaining vitamin D is crucial for me. It aids calcium absorption and plays a significant role in preventing complications related to cardiovascular disease, while also enhancing immune response.
Read More
9.5
Strong immunity
Over the past two years, I've taken vitamin D exclusively for prevention, achieving optimal levels of 80-90 ng/ml. I've noticed remarkable immunity, not contracting any illnesses during this period. Additionally, my hair, skin, and nails have improved significantly. Vitamin D-3 is effective in preventing various diseases, including those impacting cardiovascular disease.
Read More
9.5
Essential health support
Vitamin D helps maintain healthy bones and gums and supports cardiovascular function. I take my supplement in the morning with fatty foods. Many lack sufficient vitamin D, and higher doses are warranted. I appreciate this essential nutrient for overall health.
9.5
Pain relief
After taking 5,000 IU of vitamin D for severe toothache, I noticed a significant reduction in pain within two days. It's crucial for addressing deficiencies that affect bones and teeth, and aids in protecting against cardiovascular disease.
